TREATMENT OF CHRONIC HEART FAILURE WITH PRESERVED LEFT VENTRICULAR EJECTION FRACTION IN PATIENTS WITH HYPERTENSION DISEASE: POTENTIAL THERAPEUTIC ROLE OF STATINES

TREATMENT OF CHRONIC HEART FAILURE WITH PRESERVED LEFT VENTRICULAR EJECTION FRACTION IN PATIENTS WITH HYPERTENSION DISEASE: POTENTIAL THERAPEUTIC ROLE OF STATINES

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The prospective randomized trial included 167 patients with functional class II-III of chronic heart failure (CHF) and a preserved left ventricular ejection fraction (LVEF) affected by hypertensive disease of stage III.In addition to antihypertensive therapy with aireloom timeless odyssey perindopril and verapamil SR (n = 85) or amlodipine (n = 82), atorvastatin was prescribed, which was regularly taken by 50.6% and 48.

8% of patients, respectively.After 12 months, patients in each treatment arm showed improvement in the clinical condition and quality of life, an increase in 6MWD (6-minute walk distance).The patients receiving atorvastatin demonstrated a significant reduction in the N-terminal prohormone of brain natriuretic peptide ic berlin eyewear st. louis (NT-proBNP or BNPT) level, and a tendency to improve a diastolic LV function.

Adding atorvastatin to the therapy of CHF with preserved LVEF may reasonably improve the prognosis of patients.